This site uses Akismet to reduce spam. aTyr’s primary focus is ATYR1923, a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in interstitial lung diseases. %PDF-1.4 Her talk was titled “Age against the machine: How the aging microenvironment governs response to therapy.”. “AI is making precision medicine more predictive,” Elemento concluded. Telephone: 215-440-9300 Weeraratna drew our attention to the fact that by 2050, a quarter of the world’s population will be more than 60 years old, the age beyond which most cancer diagnoses and deaths are encountered, making it a significant public health burden. << /Type /XObject Get the latest blog posts delivered to your inbox. Following the resounding success of the First Virtual Annual Meeting with more than 61,000 attendees in April, the AACR delivered a sensational Opening Ceremony for the organization’s Virtual Annual Meeting II, which started Monday. Learn how your comment data is processed. Of these patients, 68.5 percent identified as non-Hispanic white, while 22 percent identified as non-Hispanic Black. Philadelphia, PA 19106-4404  USA To further refine your search, toggle appropriate sections on or off. /ModDate (D:20200622172007+00'00') © 2020 GlobeNewswire, Inc. All Rights Reserved. Details of the abstract and poster presentation are as follows: Title: Domain-Specific Antibodies to Neuropilin 2 Implicate VEGF-C and not Semaphorin 3F in Breast Cancer Stem Cell Function Authors: Leslie A. Nangle, Luke Burman, Hira L. Goel, Zhiwen Xu, Kristina Hamel, Nathaniel Bloom, Arthur M. Mercurio. Human studies conducted elsewhere in parallel demonstrated younger melanoma patients benefiting from the anti-VEGF treatment bevacizumab (Avastin), with no effect in older patients. /CreationDate (D:20200622172007+00'00') The nine AACR Journals publish high-impact articles that span the cancer research continuum. A study presented by Fei Wang, who is affiliated with Vanderbilt University Medical Center and Shadong University in China, examined the impact of clinical and environmental factors on survival disparities in patients with triple-negative breast cancer (TNBC). Mardis introduced the AACR President and Annual Meeting 2020 Program Chair Antoni Ribas, MD, FAACR, who provided his remarks for the Opening Plenary Session, “Turning Science into Lifesaving Care.”, “The program for this second Virtual Annual Meeting will be broad in scope, covering the cutting-edge science being conducted across the spectrum of cancer research,” noted Ribas. While white and Black individuals have roughly similar rates of overall cancer diagnoses, Black patients with cancer are more likely to die than white patients. These therapies, however, don’t work for solid cancers, and are expensive. Trial completion rates were similar between Black and white patients. These forward-looking statements also reflect our current views about our plans, intentions, expectations, strategies and prospects, which are based on the information currently available to us and on assumptions we have made. ���� JFIF ��(ICC_PROFILE mntrRGB XYZ acsp �� �- desc � trXYZ d gXYZ x bXYZ � rTRC � (gTRC � (bTRC � (wtpt � cprt �. Bencomo-Alvarez noted that these differences may be due to multiple environmental factors. The program included an impressive lineup of influential speakers, including Congresswoman Nancy Pelosi (D-California), Speaker of the U.S. House of Representatives; Senator Roy Blunt (R-Missouri), Chairman of the Appropriations Subcommittee on Labor, Health and Human Services, and Education; and Richard Pazdur, MD, director of the U.S. Food and Drug Administration’s Oncology Center of Excellence. In this study, Wang and colleagues investigated whether racial disparities in incidence and mortality were dependent on various clinical and environmental factors. Given that the existing CAR T-cell therapy approaches utilize viruses as vectors, Marson discussed the possibility of moving beyond viruses and utilizing revolutionary technologies with flexible platforms, such as CRISPR, for the non-viral engineering of T cells. Each Black patient was matched with a white patient from the same arm of the same clinical trial; patients were matched by age, gender, and tumor stage. These factors could discourage individuals from visiting a physician and may therefore affect health outcomes in those residing at the border, he explained. /Filter /DCTDecode “We hypothesize that biological factors…are one potential explanation for the cause of this disparity,” Liu noted, adding that features of the tumor, the patient, or tumor-host interactions may be relevant. Preclinical studies by Weeraratna’s team showed the influence of aged fibroblasts in promoting metastasis compared to fibroblasts from younger patients, and the ability of melanoma cells to metastasize more rapidly in older mice than in younger mice, even when the metastatic cells migrated to the lung at about the same rate. Wang proposed that equity in health care could help eliminate survival disparities between non-Hispanic Black and non-Hispanic white patients. Further refinement to suppress adenosine, which can hinder T-cell function, resulted in the identification of two genes that could make T cells proliferate efficiently. Aged fibroblasts also had an influence on melanoma tumor metabolism, by promoting increased uptake of fatty acids through the fatty acid transporter FATP2. The abstract is available online and will be included in an online-only Proceedings supplement to the AACR journal Cancer Research following the AACR Virtual Annual Meeting II. A study presented by Alfonso Bencomo-Alvarez, PhD, a postdoctoral research associate at Texas Tech University Health Sciences Center El Paso, examined disparities in blood cancers at the United States/Mexico border. Neoleukin Therapeutics Announces Multiple Presentations at American Association for Cancer Research (AACR) Virtual Annual Meeting II Email Print Friendly Share May 15, 2020 07:00 ET | … Get the latest blog posts delivered to your inbox. 615 Chestnut St., 17th Floor Daniel Diniz De Carvalho, PhD, a senior scientist at the Princess Margaret Cancer Centre and associate professor in the Department of Medical Biophysics at the University of Toronto, presented his talk, titled “Turning the science of epigenetics into novel cancer early detection, classification, and monitoring approaches.”. Forward-looking statements are usually identified by the use of words such as “anticipates,” “believes,” “estimates,” “expects,” “intends,” “may,” “plans,” “projects,” “seeks,” “should,” “will,” and variations of such words or similar expressions. Session: June 22; 9:00 AM, Circulating Tumor DNA for Patient StratificationA multi-gene prostate cancer liquid biopsy with > 92% accuracy in diagnosis and assessment of disease statusLead author: Irvin ModlinSession: June 23; 10:05 AM, Cancer Increases in Younger Populations: Where Are They Coming from?